ARA-290 (Cibinetide) Research-Grade Innate Repair Receptor (IRR) Agonist

Product Overview

ARA-290 is a synthetic 11-amino acid peptide derived from the structure of Erythropoietin (EPO). Unlike standard EPO, which binds to the homodimeric EPO receptor to stimulate red blood cell production (erythropoiesis), ARA-290 is specifically engineered to be non-erythropoietic.

In scientific literature, ARA-290 is distinguished by its high-affinity binding to the Innate Repair Receptor (IRR)—a heterocomplex consisting of the EPO receptor and the CD131 (beta common) receptor. This receptor is typically expressed only during periods of cellular stress, hypoxia, or tissue injury. By selectively activating the IRR, ARA-290 initiates a potent anti-inflammatory and cytoprotective signaling cascade. It has been observed to inhibit the production of pro-inflammatory cytokines and prevent apoptosis without the cardiovascular risks associated with elevated hematocrit. This makes it a premier compound for research into neuropathic pain, small fiber neuropathy, and chronic inflammatory conditions.

Primary Research Applications

Under doctor-reviewed scientific literature, ARA-290 is frequently utilized in in vitro and animal model studies to observe:

• Neuroprotection & Nerve Repair: Investigating the stabilization of mitochondrial membranes in neurons and the promotion of small nerve fiber density in models of peripheral neuropathy.

• Neuropathic Pain Modulation: Observing the reduction of allodynia and hyperalgesia through the suppression of neuroinflammation in the spinal cord and dorsal root ganglia.

• Ischemia-Reperfusion Injury: Measuring the peptide’s ability to minimize tissue damage and programmed cell death following a loss of blood flow in cardiac and renal models.

• Metabolic Inflammation: Tracking the improvement of glucose homeostasis and the reduction of systemic inflammation in models of type-2 diabetes and sarcoidosis.

The BioRegen Standard

When you source your ARA-290 from BioRegen Peptides, you are backed by our five core pillars of quality and service:

• Uncompromising Purity: Every batch is independently third-party tested to guarantee >99% purity and molecular integrity, ensuring your neurological research data is precise and reproducible.

• Doctor-Reviewed Accuracy: All product specifications and research handling guidelines are medically reviewed for absolute scientific accuracy.

• Unbeatable Value: Premium, verified research compounds at industry-disrupting prices.

• Fast, US-Based Shipping: Stocked physically in the USA to bypass customs delays and arrive at your lab in days.

• Dedicated Support: Have a question about the CD131 receptor heterocomplex? Email our US-based team at support@bioregenpeptides.com for a rapid response.

Product Specifications

• Nomenclature: ARA-290, Cibinetide

• Amino Acid Sequence: Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser

• CAS Number: 1208240-58-1

• Molecular Formula: $C_{51}H_{84}N_{16}O_{21}$

• Purity: >99% (Verified via HPLC/MS)

• Format: Lyophilized Powder

---

Regulatory Notice: This product is sold strictly for laboratory and research purposes only. It is not intended for human consumption, diagnostic, therapeutic, or prophylactic use. Please refer to our doctor-reviewed handling guidelines for proper research protocols.