CJC-1295 No DAC (Modified GRF 1-29) Research-Grade Growth Hormone-Releasing Hormone (GHRH) Analogue

Product Overview

CJC-1295 No DAC, scientifically referred to as Modified GRF 1-29, is a synthetic, 29-amino acid polypeptide analogue of the naturally occurring Growth Hormone-Releasing Hormone (GHRH). While standard Sermorelin (GRF 1-29) has a biological half-life of less than five minutes due to rapid enzymatic cleavage, CJC-1295 No DAC features four strategic amino acid substitutions that significantly enhance its metabolic stability.

In scientific literature, these modifications (specifically at positions 2, 8, 15, and 27) protect the peptide from degradation by the enzyme dipeptidyl peptidase-IV (DPP-IV). This results in an extended half-life of approximately 30 minutes, allowing for a more profound stimulation of the pituitary gland. Unlike the “With DAC” version, which provides a constant elevation of GH levels, CJC-1295 No DAC preserves the natural, pulsatile rhythm of endogenous growth hormone release. This makes it a critical compound for researchers studying the somatotropic axis while maintaining the physiological integrity of the body’s natural feedback loops.

Primary Research Applications

Under doctor-reviewed scientific literature, CJC-1295 No DAC is frequently utilized in in vitro and animal model studies to observe:

• Pulsatile GH Amplification: Investigating the enhancement of natural growth hormone “pulses” and the subsequent rise in systemic Insulin-like Growth Factor 1 (IGF-1).

• Metabolic Efficiency: Observing the mobilization of adipose tissue and the regulation of glucose metabolism in endocrine research models.

• Cellular Regeneration: Tracking the acceleration of protein synthesis, collagen production, and tissue repair following induced injury.

• Deep Sleep Architecture: Measuring the impact of GHRH analogues on slow-wave sleep patterns, which are highly correlated with nocturnal GH secretion.

The BioRegen Standard

When you source your CJC-1295 No DAC from BioRegen Peptides, you are backed by our five core pillars of quality and service:

• Uncompromising Purity: Every batch is independently third-party tested to guarantee >99% purity and molecular integrity, ensuring your endocrine models remain precise.

• Doctor-Reviewed Accuracy: All product specifications and research handling guidelines are medically reviewed for absolute scientific accuracy.

• Unbeatable Value: Premium, verified research compounds at industry-disrupting prices.

• Fast, US-Based Shipping: Stocked physically in the USA to bypass customs delays and arrive at your lab in days.

• Dedicated Support: Have a question about a batch-specific COA? Email our US-based team at support@bioregenpeptides.com for a rapid response.

Product Specifications

• Nomenclature: CJC-1295 No DAC, Modified GRF 1-29 (Growth Hormone Releasing Factor)

• Amino Acid Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2

• CAS Number: 863288-34-0

• Molecular Formula: C152H252N44O42

• Purity: >99% (Verified via HPLC/MS)

• Format: Lyophilized Powder

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Regulatory Notice: This product is sold strictly for laboratory and research purposes only. It is not intended for human consumption, diagnostic, therapeutic, or prophylactic use. Please refer to our doctor-reviewed handling guidelines for proper research protocols.