LL-37 (Cathelicidin) Research-Grade Antimicrobial & Immunomodulatory Peptide

Product Overview

LL-37 is a 37-amino acid, linear cationic peptide and the only member of the Cathelicidin family found in humans. Naturally produced by epithelial cells and various immune cells (including neutrophils and macrophages), LL-37 is a critical component of the innate immune system.

In scientific literature, LL-37 is distinguished by its amphipathic alpha-helical structure, which allows it to bind directly to the negatively charged phospholipids of bacterial membranes. This interaction leads to membrane disruption and rapid bacterial lysis. Beyond its direct antimicrobial activity against Gram-positive and Gram-negative bacteria, fungi, and viral envelopes, LL-37 functions as a potent Alarmin. It modulates the inflammatory response by binding to Formyl Peptide Receptor-Like 1 (FPRL1) and Toll-like receptors (TLRs), thereby regulating cytokine production and promoting chemotaxis. Its multifaceted role in stimulating angiogenesis and re-epithelialization makes it a premier compound for research into wound healing, chronic infection, and autoimmune pathology.

Primary Research Applications

Under doctor-reviewed scientific literature, LL-37 is frequently utilized in in vitro and animal model studies to observe:

• Broad-Spectrum Antimicrobial Efficacy: Investigating the disruption of bacterial cell walls and the inhibition of biofilm formation in multidrug-resistant strains.

• Wound Healing & Angiogenesis: Observing the stimulation of endothelial cell proliferation and the acceleration of tissue repair in diabetic or compromised dermal models.

• Immunomodulation & TLR Signaling: Measuring the peptide’s ability to neutralize lipopolysaccharides (LPS) and modulate the release of pro-inflammatory cytokines.

• Autoimmune & Inflammatory Pathology: Tracking the role of LL-37 in the pathogenesis of conditions such as psoriasis, rosacea, and rheumatoid arthritis.

The BioRegen Standard

When you source your LL-37 from BioRegen Peptides, you are backed by our five core pillars of quality and service:

• Uncompromising Purity: Every batch is independently third-party tested to guarantee >99% purity and molecular integrity, ensuring your immunological data is exact and reproducible.

• Doctor-Reviewed Accuracy: All product specifications and research handling guidelines are medically reviewed for absolute scientific accuracy.

• Unbeatable Value: Premium, verified research compounds at industry-disrupting prices.

• Fast, US-Based Shipping: Stocked physically in the USA to bypass customs delays and arrive at your lab in days.

• Dedicated Support: Have a question about FPRL1 receptor interaction? Email our US-based team at support@bioregenpeptides.com for a rapid response.

Product Specifications

• Nomenclature: LL-37 (Human Cathelicidin Fragment)

• Amino Acid Sequence: Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser

• CAS Number: 154947-66-7

• Molecular Formula: $C_{205}H_{340}N_{60}O_{53}$

• Purity: >99% (Verified via HPLC/MS)

• Format: Lyophilized Powder

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Regulatory Notice: This product is sold strictly for laboratory and research purposes only. It is not intended for human consumption, diagnostic, therapeutic, or prophylactic use. Please refer to our doctor-reviewed handling guidelines for proper research protocols.