PT-141 (Bremelanotide) Research-Grade Melanocortin Receptor Agonist

Product Overview

PT-141, also known as Bremelanotide, is a synthetic cyclic heptapeptide (7 amino acids) derived from the naturally occurring $\alpha$-Melanocyte-Stimulating Hormone ($\alpha$-MSH). While originally developed as a derivative of the tanning peptide Melanotan II, PT-141 was found to possess a unique mechanism for addressing sexual dysfunction by targeting the central nervous system (CNS) rather than the peripheral vascular system.

In scientific literature, PT-141 is distinguished by its non-selective agonism of the melanocortin receptors, primarily the MC3R and MC4R located in the hypothalamus. Unlike traditional treatments that rely on nitric oxide-mediated vasodilation (such as PDE5 inhibitors), PT-141 bypasses the cardiovascular system entirely. It acts directly on the brain’s neural pathways to increase sexual desire and arousal. By stimulating the paraventricular nucleus (PVN) and the medial preoptic area (mPOA), PT-141 facilitates a neurogenic response, making it a critical compound for research into Hypoactive Sexual Desire Disorder (HSDD) and treatment-resistant erectile dysfunction.

 

Primary Research Applications

Under doctor-reviewed scientific literature, PT-141 is frequently utilized in in vitro and animal model studies to observe:

• Central Arousal Pathways: Investigating the activation of MC3R and MC4R to enhance sexual motivation and appetitive behaviors in both male and female models.

• Neurotransmitter Modulation: Observing the secondary release of dopamine and oxytocin in the mesolimbic reward circuits following melanocortin activation.

• Energy Homeostasis & Metabolism: Tracking the influence of MC4R stimulation on food intake regulation and systemic energy expenditure.

• Psychogenic Dysfunction Mitigation: Measuring the peptide’s efficacy in overcoming neural barriers to sexual response independent of vascular nitric oxide mechanisms.

The BioRegen Standard

When you source your PT-141 from BioRegen Peptides, you are backed by our five core pillars of quality and service:

• Uncompromising Purity: Every batch is independently third-party tested to guarantee >99% purity and molecular integrity, ensuring your neuro-endocrine data is exact.

• Doctor-Reviewed Accuracy: All product specifications and research handling guidelines are medically reviewed for absolute scientific accuracy.

• Unbeatable Value: Premium, verified research compounds at industry-disrupting prices.

• Fast, US-Based Shipping: Stocked physically in the USA to bypass customs delays and arrive at your lab in days.

• Dedicated Support: Have a question about MC3/MC4 receptor affinity? Email our US-based team at support@bioregenpeptides.com for a rapid response.

Product Specifications

• Nomenclature: PT-141, Bremelanotide Acetate

• Amino Acid Sequence: Ac-Nle-cyclo(Asp-His-D-Phe-Arg-Trp-Lys)-OH

• CAS Number: 1607799-13-

• Molecular Formula: $C_{50}H_{68}N_{14}O_{10}$

• Purity: >99% (Verified via HPLC/MS)

• Format: Lyophilized Powder

   

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Regulatory Notice: This product is sold strictly for laboratory and research purposes only. It is not intended for human consumption, diagnostic, therapeutic, or prophylactic use. Please refer to our doctor-reviewed handling guidelines for proper research protocols.