MOTS-c Research-Grade Mitochondrial-Derived Peptide

Product Overview

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a highly unique, 16-amino acid peptide. Unlike the vast majority of peptides that are encoded by the nuclear genome, MOTS-c is an endogenous mitochondrial-derived peptide (MDP) encoded entirely by the mitochondrial DNA.

In scientific literature, MOTS-c is widely recognized as an “exercise mimetic” and a master regulator of metabolic homeostasis. It functions primarily by acting on the folate-methionine cycle and robustly activating AMPK (AMP-activated protein kinase), the cellular energy sensor. Through a process known as retrograde signaling, MOTS-c can translocate from the mitochondria to the nucleus to directly regulate gene expression in response to metabolic stress. This profound ability to enhance cellular glucose uptake, improve insulin sensitivity, and promote fatty acid oxidation makes it a premier compound for research into obesity, type-2 diabetes, and age-related metabolic decline.

Primary Research Applications

Under doctor-reviewed scientific literature, MOTS-c is frequently utilized in in vitro and animal model studies to observe:

• Metabolic Regulation & AMPK Activation: Investigating the activation of cellular energy sensors and the systemic improvement of glucose clearance and insulin sensitivity.

• Exercise Mimetic Pathways: Observing the enhancement of skeletal muscle function, metabolic flexibility, and fatty acid oxidation without induced physical exertion.

• Diet-Induced Obesity Models: Tracking the prevention of insulin resistance and the reduction of fat accumulation in subjects subjected to high-fat diets.

• Mitochondrial Retrograde Signaling: Measuring the communication between mitochondrial DNA and nuclear DNA to mitigate age-related metabolic dysfunction and cellular senescence.

The BioRegen Standard

When you source your MOTS-c from BioRegen Peptides, you are backed by our five core pillars of quality and service:

• Uncompromising Purity: Every batch is independently third-party tested to guarantee >99% purity and molecular integrity, ensuring your metabolic models are exact and uncontaminated.

• Doctor-Reviewed Accuracy: All product specifications and research handling guidelines are medically reviewed for absolute scientific accuracy.

• Unbeatable Value: Premium, verified research compounds at industry-disrupting prices.

• Fast, US-Based Shipping: Stocked physically in the USA to bypass customs delays and arrive at your lab in days.

• Dedicated Support: Have a question about a batch-specific COA? Email our US-based team at support@bioregenpeptides.com for a rapid response.

Product Specifications

• Nomenclature: MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c)

• Amino Acid Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg

• CAS Number: 1627580-64-6

• Molecular Formula: C101H152N28O22S2

• Purity: >99% (Verified via HPLC/MS)

• Format: Lyophilized Powder

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Regulatory Notice: This product is sold strictly for laboratory and research purposes only. It is not intended for human consumption, diagnostic, therapeutic, or prophylactic use. Please refer to our doctor-reviewed handling guidelines for proper research protocols.